Monocyte Spreading by Induction of ET Thrombin Receptor Activation Inhibits
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Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation.
OBJECTIVE The serine protease thrombin can dramatically alter endothelial gene expression in a manner that confers a proinflammatory phenotype. Recent studies have identified the Kruppel-like factor 2 (KLF2) as a critical regulator of endothelial gene expression. Herein, we provide evidence that KLF2 inhibits thrombin-mediated endothelial activation via alterations in expression of its principa...
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تاریخ انتشار 1998